Protective Mechanisms of Map Kinase Phosphatase 5 in Adipose Tissue Fibrosis, Hepatic Steatosis and Atherosclerosis

Grant number: 1149062 | Funding period: 2018 - 2020

Completed

Abstract

Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Recently, we found that MKP5, a molecule that restricts intracellular signaling, plays a central role in preventing these diseases. This collaborative project will elucidate how precisely MKP5 acts and explore how this molecule can be targeted for the development of novel therapeutic strategies in prevention and treatment of human metabolic diseases.

Related publications (2)

Author Correction: Sex-specific adipose tissue imprinting of regulatory T cells (Nature, (2020), 579, 7800, (581-585), 10.1038/s41586-020-2040-3)

A Vasanthakumar, D Chisanga, J Blume, R Gloury, K Britt, DC Henstridge, Y Zhan, SV Torres, S Liene, N Collins, E Cao, T Sidwell, C Li, RG Spallanzani, Y Liao, PA Beavis, T Gebhardt, N Trevaskis, SL Nutt, JD Zajac

2021-03-25

In Fig. 1a of this Article, the y-axis label should read ‘Fat to lean mass (ratio)’ rather than ‘Lean to fat mass (ratio)’. In add..

Sex-specific adipose tissue imprinting of regulatory T cells

2020-03-26

Adipose tissue is an energy store and a dynamic endocrine organ<sup>1,2</sup>. In particular, visceral adipose tissue (VAT) is cri..

University of Melbourne Researchers

Axel Kallies